--- a/src/Mayaqua/Encrypt.c
+++ b/src/Mayaqua/Encrypt.c
@@ -120,6 +120,7 @@
 #include <openssl/rand.h>
 #include <openssl/engine.h>
 #include <openssl/bio.h>
+#include <openssl/bn.h>
 #include <openssl/x509.h>
 #include <openssl/pkcs7.h>
 #include <openssl/pkcs12.h>
@@ -128,6 +129,7 @@
 #include <openssl/md4.h>
 #include <openssl/hmac.h>
 #include <openssl/sha.h>
+#include <openssl/rsa.h>
 #include <openssl/des.h>
 #include <openssl/aes.h>
 #include <openssl/dh.h>
@@ -627,7 +629,7 @@ UINT CipherProcess(CIPHER *c, void *iv, void *dest, void *src, UINT size)
 		return 0;
 	}
 
-	if (EVP_CipherFinal(c->Ctx, ((UCHAR *)dest) + (UINT)r, &r2) == 0)
+	if (EVP_CipherFinal_ex(c->Ctx, ((UCHAR *)dest) + (UINT)r, &r2) == 0)
 	{
 		return 0;
 	}
@@ -926,6 +928,7 @@ BUF *BigNumToBuf(const BIGNUM *bn)
 // Initialization of the lock of OpenSSL
 void OpenSSL_InitLock()
 {
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	UINT i;
 
 	// Initialization of the lock object
@@ -939,11 +942,13 @@ void OpenSSL_InitLock()
 	// Setting the lock function
 	CRYPTO_set_locking_callback(OpenSSL_Lock);
 	CRYPTO_set_id_callback(OpenSSL_Id);
+#endif
 }
 
 // Release of the lock of OpenSSL
 void OpenSSL_FreeLock()
 {
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	UINT i;
 
 	for (i = 0;i < ssl_lock_num;i++)
@@ -955,11 +960,13 @@ void OpenSSL_FreeLock()
 
 	CRYPTO_set_locking_callback(NULL);
 	CRYPTO_set_id_callback(NULL);
+#endif
 }
 
 // Lock function for OpenSSL
 void OpenSSL_Lock(int mode, int n, const char *file, int line)
 {
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	LOCK *lock = ssl_lock_obj[n];
 
 	if (mode & CRYPTO_LOCK)
@@ -972,12 +979,15 @@ void OpenSSL_Lock(int mode, int n, const char *file, int line)
 		// Unlock
 		Unlock(lock);
 	}
+#endif
 }
 
 // Return the thread ID
 unsigned long OpenSSL_Id(void)
 {
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	return (unsigned long)ThreadId();
+#endif
 }
 
 // Get the display name of the certificate
@@ -1901,8 +1911,8 @@ X509 *NewX509(K *pub, K *priv, X *ca, NAME *name, UINT days, X_SERIAL *serial)
 	X509_set_version(x509, 2L);
 
 	// Set the Expiration
-	t1 = X509_get_notBefore(x509);
-	t2 = X509_get_notAfter(x509);
+	t1 = X509_getm_notBefore(x509);
+	t2 = X509_getm_notAfter(x509);
 	if (!UINT64ToAsn1Time(t1, notBefore))
 	{
 		FreeX509(x509);
@@ -2043,8 +2053,8 @@ X509 *NewRootX509(K *pub, K *priv, NAME *name, UINT days, X_SERIAL *serial)
 	X509_set_version(x509, 2L);
 
 	// Set the Expiration
-	t1 = X509_get_notBefore(x509);
-	t2 = X509_get_notAfter(x509);
+	t1 = X509_getm_notBefore(x509);
+	t2 = X509_getm_notAfter(x509);
 	if (!UINT64ToAsn1Time(t1, notBefore))
 	{
 		FreeX509(x509);
@@ -2697,6 +2707,43 @@ bool RsaCheckEx()
 
 	return false;
 }
+
+// RSA key generation
+static RSA *RsaGenKey(UINT bit, BN_ULONG e)
+{
+	RSA *rsa = NULL;
+	char errbuf[MAX_SIZE];
+	BIGNUM *bne = NULL;
+
+	if ((bne = BN_new()) == NULL)
+	{
+		Debug("BN_new: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
+		return NULL;
+	}
+	if (BN_set_word(bne, e) == 0)
+	{
+		Debug("BN_set_word: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
+		goto fail;
+	}
+	if ((rsa = RSA_new()) == NULL)
+	{
+		Debug("RSA_new: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
+		goto fail;
+	}
+	if (RSA_generate_key_ex(rsa, bit, bne, NULL) == 0)
+	{
+		Debug("RSA_generate_key_ex: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
+		goto fail;
+	}
+	BN_free(bne);
+	return rsa;
+
+fail:
+	RSA_free(rsa);
+	BN_free(bne);
+	return NULL;
+}
+
 bool RsaCheck()
 {
 	RSA *rsa;
@@ -2710,12 +2757,11 @@ bool RsaCheck()
 	// Key generation
 	Lock(openssl_lock);
 	{
-		rsa = RSA_generate_key(bit, RSA_F4, NULL, NULL);
+		rsa = RsaGenKey(bit, RSA_F4);
 	}
 	Unlock(openssl_lock);
 	if (rsa == NULL)
 	{
-		Debug("RSA_generate_key: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
 		return false;
 	}
 
@@ -2780,12 +2826,11 @@ bool RsaGen(K **priv, K **pub, UINT bit)
 	// Key generation
 	Lock(openssl_lock);
 	{
-		rsa = RSA_generate_key(bit, RSA_F4, NULL, NULL);
+		rsa = RsaGenKey(bit, RSA_F4);
 	}
 	Unlock(openssl_lock);
 	if (rsa == NULL)
 	{
-		Debug("RSA_generate_key: err=%s\n", ERR_error_string(ERR_get_error(), errbuf));
 		return false;
 	}
 
@@ -3895,7 +3940,7 @@ X *X509ToX(X509 *x509)
 				{
 					if (OBJ_obj2nid(ad->method) == NID_ad_ca_issuers && ad->location->type == GEN_URI)
 					{
-						char *uri = (char *)ASN1_STRING_data(ad->location->d.uniformResourceIdentifier);
+						char *uri = (char *)ASN1_STRING_get0_data(ad->location->d.uniformResourceIdentifier);
 
 						if (IsEmptyStr(uri) == false)
 						{
@@ -4108,7 +4153,9 @@ void Rand(void *buf, UINT size)
 // Delete a thread-specific information that OpenSSL has holded
 void FreeOpenSSLThreadState()
 {
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	ERR_remove_state(0);
+#endif
 }
 
 // Release the Crypt library
@@ -4130,12 +4177,14 @@ void InitCryptLibrary()
 	CheckIfIntelAesNiSupportedInit();
 //	RAND_Init_For_SoftEther()
 	openssl_lock = NewLock();
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
 	SSL_library_init();
 	//OpenSSL_add_all_algorithms();
 	OpenSSL_add_all_ciphers();
 	OpenSSL_add_all_digests();
 	ERR_load_crypto_strings();
 	SSL_load_error_strings();
+#endif
 
 	ssl_clientcert_index = SSL_get_ex_new_index(0, "struct SslClientCertInfo *", NULL, NULL, NULL);
 
--- a/src/Mayaqua/Encrypt.h
+++ b/src/Mayaqua/Encrypt.h
@@ -105,7 +105,7 @@
 #ifndef	ENCRYPT_H
 #define	ENCRYPT_H
 
-#if OPENSSL_VERSION_NUMBER >= 0x10100000L
+#if OPENSSL_VERSION_NUMBER >= 0x10100000L && !defined(OPENSSL_NO_CHACHA) && !defined(LIBRESSL_VERSION_NUMBER)
 #define USE_OPENSSL_AEAD_CHACHA20POLY1305
 #endif
 
--- a/src/Mayaqua/Network.c
+++ b/src/Mayaqua/Network.c
@@ -18172,7 +18172,7 @@ struct ssl_ctx_st *NewSSLCtx(bool server_mode)
 	SSL_CTX_set_ecdh_auto(ctx, 1);
 #endif	// SSL_CTX_set_ecdh_auto
 
-#if OPENSSL_VERSION_NUMBER >= 0x1010100fL
+#if OPENSSL_VERSION_NUMBER >= 0x1010100fL && !defined(LIBRESSL_VERSION_NUMBER)
 	// For compatibility with VPN 3.0 or older
 	SSL_CTX_set_security_level(ctx, 0);
 #endif
--- a/src/Mayaqua/Secure.c
+++ b/src/Mayaqua/Secure.c
@@ -127,6 +127,7 @@
 #include <openssl/pkcs7.h>
 #include <openssl/pkcs12.h>
 #include <openssl/rc4.h>
+#include <openssl/rsa.h>
 #include <openssl/md5.h>
 #include <openssl/sha.h>
 #include <Mayaqua/Mayaqua.h>