diff --git a/lang/perl/perlmod.mk b/lang/perl/perlmod.mk
index 5a91c23a5a..db83d603d0 100644
--- a/lang/perl/perlmod.mk
+++ b/lang/perl/perlmod.mk
@@ -25,6 +25,9 @@ MOD_CFLAGS_PERL:=-D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64 $(TARGET_CFLAGS) $(T
 ifdef CONFIG_PERL_THREADS
 	MOD_CFLAGS_PERL+= -D_REENTRANT -D_GNU_SOURCE
 endif
+ifdef CONFIG_USE_MUSL
+	MOD_CFLAGS_PERL+= -D_LARGEFILE64_SOURCE
+endif
 
 # Module install prefix
 PERL_SITELIB:=/usr/lib/perl5/$(PERL_VERSION)